Immunology (Lippincott's Illustrated Reviews Series) by Doan Thao & Melvold Roger & Viselli Susan & Waltenbaugh Carl

Author:Doan, Thao & Melvold, Roger & Viselli, Susan & Waltenbaugh, Carl [Doan, Thao]
Language: eng
Format: epub
Publisher: Lippincott Williams & Wilkins
Published: 2012-12-19T00:00:00+00:00

Figure 14.2

Asthma. Asthma is a reversible airway obstruction often caused by the release of inflammatory mediators from mast cells upon encounter with allergen. These inflammatory mediators cause the loosening of tight junctions in the bronchiole epithelium, increased capillary permeability, and spasmatic contraction of smooth muscle surrounding the bronchi. This temporarily decreases the size of the bronchial lumen, resulting in shortness of breath. Bronchospasms triggered by nonimmunologic stimuli such as cold, viral infections, and exercise, also stimulate the same airway inflammation.

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